There are seven distinct types of FMDV serotypes: O, A, C, Asia 1, SAT 1, SAT 2, and SAT 3. Our results could provide meaningful information to understand comprehensive characteristic of Sea-97 lineage.įoot-and-mouth disease (FMD), a contagious disease that affects cloven-hoofed animals, is caused by FMD virus (FMDV), a member of the Aphthovirus genus within the Picornaviridae family. Substitutions at antigenically important sites may affect the efficacy of the vaccine, suggesting the need for appropriate vaccine strains. The evolution rate of this lineage was estimated to be 1.2 × 10 –2 substitutions/site/year and there were many differences in amino acid residues compared to vaccine strain. During this evolutionary process, Sea-97 lineage, which was initially found only in some countries in Southeast Asia, gradually spread to East Asia. After the emergence of G2 from G1, the genetic diversity of Sea-97 increased sharply, causing divergence into G3, G4 and G5. Phylogenetic analysis revealed that Sea-97 lineage can be classified into five groups (G1–G5). Thus, we conducted phylogenetic and evolutionary analysis of Sea-97 using 224 VP1 sequences of FMDV A/ASIA during 19. However, Sea-97 lineage has not been well studied since its first outbreak in Thailand in 1997. Foot-and-mouth disease virus (FMDV) A/ASIA/Sea-97 is a predominant lineage in Southeast Asia and East Asia.
0 kommentar(er)
